When that failed, she tried to put the offending audience members in a time out: "If you're going to smoke cigarettes, I'm not doing a show."
Things quickly became heated when Madonna realized that her schoolmarm-esque chiding was getting her nowhere.
"All right? Are we going to play that game? I'm not kidding. I can't sing if you smoke," the "Human Nature" singer fumed. Trying desperately to speak their language, she added: "Entiendes?"
Finally, her line of sight met the perpetrator but, shockingly, they continued to puff away with abandon. "You're looking right at me and smoking cigarettes, like I'm a stupid fucking idiot," the flabbergasted 54-year-old exclaimed.
TMZ reports that cigarette standoff was ultimately resolved, and Madonna carried on with the concert and the smoker was never heard from again.